F. Harrison

BatR: A novel regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms

This study identifies PA3049, renamed BatR, as a key regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms, showing its role in stress response and antimicrobial resistance.

A new model of endotracheal tube biofilm identifies combinations of matrix-degrading enzymes and antimicrobials able to eradicate biofilms of pathogens that cause ventilator-associated pneumonia

This paper introduces an in vitro model of endotracheal tube biofilms that demonstrates the effectiveness of combining matrix-degrading enzymes with antimicrobials to eradicate pathogens causing ventilator-associated pneumonia.

Differential development of antibiotic resistance and virulence between Acinetobacter species

This study compares antibiotic resistance and virulence between Acinetobacter lwoffii and A. baumannii, finding A. lwoffii has fewer resistance genes, more DNA defense systems, and reduced ability to develop resistance.

Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys

This study investigates the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys, finding synergistic effects in some vinegars against P. aeruginosa and S. aureus.

How long does it take to cue a Pseudomonas aeruginosa chronic infection phenotype in the lab? Insights from transcriptome analysis in a cystic fibrosis lung model.

This study investigates how quickly Pseudomonas aeruginosa develops chronic infection traits in a CF lung model over 7 days, showing increased antibiotic tolerance and biofilm formation.

An assessment of the evidence for antibacterial activity of stinging nettle (Urtica dioica) extracts

This study reviews evidence for antibacterial activity of Urtica dioica extracts and finds no strong evidence for clinically useful antimicrobial compounds, suggesting traditional uses may rely on carrier substances.

Transcriptome analysis of Pseudomonas aeruginosa biofilm infection in an ex vivo pig model of the cystic fibrosis lung

The paper compares Pseudomonas aeruginosa transcriptomes in an ex vivo pig lung model and synthetic cystic fibrosis sputum medium to show the EVPL model better replicates in vivo biofilm infection characteristics and antimicrobial resistance.

Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa.

This study shows that Pseudomonas aeruginosa in CF-mimicking media and ex vivo models exhibits higher colistin tolerance due to poor antibiotic penetration, highlighting the need for better biofilm penetration assays.

Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients.

This paper shows a medieval remedy containing onion, garlic, wine, and bile salts has anti-biofilm activity against multiple pathogens, but requires all ingredients to work effectively.

The safety profile of Bald's eyesalve for the treatment of bacterial infections

This paper evaluates the safety of Bald's eyesalve for treating bacterial infections using in vitro, ex vivo, and in vivo models, finding mild toxicity but potential for clinical testing.

Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model

This study uses an ex-vivo lung biofilm model to assess antibiotic tolerance and virulence of Pseudomonas aeruginosa, showing minimal bacterial load reduction and increased virulence factors with certain antibiotics.

Building a better biofilm - formation of in vivo-like biofilm structures by Pseudomonas aeruginosa in a porcine model of cystic fibrosis lung infection

This study optimizes an ex vivo pig lung model to mimic in vivo Pseudomonas aeruginosa biofilm structure in CF lung infections, identifying key metabolic and genetic factors essential for biofilm formation.

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

This study develops an ex vivo pig lung model of cystic fibrosis to study Staphylococcus aureus infection, showing clinically relevant features like small colony variants and antibiotic tolerance.

Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections

This paper uses network science to analyze medieval medical texts and identifies statistically significant patterns in ingredient selection for treating infections.

The fitness of Pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment

The paper shows that QS signal molecules in Pseudomonas aeruginosa act as social public goods, with their accessibility influenced by environmental diffusivity and population structure.

Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production

This study shows that the quorum sensing molecule PQS in Pseudomonas aeruginosa increases siderophore production, which benefits non-producing cheats and affects social competition.