J. Bruce

Arbitrium phages can manipulate each other's lysis - lysogeny decisions

The paper shows that Arbitrium phages from different species can influence each other's lysis-lysogeny decisions through peptide-based communication, leading to fitness advantages and coevolution.

NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in the intestinal epithelium

This study shows that NLRP1B allele 2 in intestinal epithelial cells does not respond to VbP, unlike in macrophages, suggesting allele-dependent regulation in IECs.

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

Exploiting rodent cell blocks for intrinsic resistance to HIV-1 gene expression in human T cells

This paper edits human T cells to mimic rodent host factors, creating resistance to HIV-1 and related lentiviruses by disrupting key viral protein interactions.

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling.

The paper shows that ERBB2 inhibition in OAC cells leads to chromatin remodelling and rewiring of gene regulatory networks, enabling resistance through metabolic shifts and transcriptional regulators.

The safety profile of Bald's eyesalve for the treatment of bacterial infections

This paper evaluates the safety of Bald's eyesalve for treating bacterial infections using in vitro, ex vivo, and in vivo models, finding mild toxicity but potential for clinical testing.