Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
L. Aguinagalde, M. A. den Boer, S. Castenmiller…·S. Rooijakkers
This paper shows that modifying anti-capsular antibodies to enhance hexamerization improves complement activation and immune protection against Streptococcus pneumoniae.
S. A. Zwarthoff, K. Widmer, A. Kuipers…·S. H. M. Rooijakkers
This study shows that C1r2s2 proteases stabilize C1q binding to surface-bound IgG, with subclass-specific effects and improved phagocytosis with hexamer-enhanced IgGs.
A. R. Cruz, M. A. den Boer, J. Strasser…·S. H. M. Rooijakkers
This study shows Staphylococcal protein A inhibits IgG hexamer formation, blocking complement activation, but IgG3 can still induce complement activation despite SpA.