J. Preiner

Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding

This study shows that IgG subclass complement activation depends on their ability to form oligomers on antigen surfaces, challenging the traditional view of C1 affinity.

Dissociation of β2m from MHC Class I Triggers Formation of Noncovalent, Transient Heavy Chain Dimers

This study investigates the formation of non-covalent MHC-I heavy chain dimers after dissociation of β2m and peptide, revealing a dimerization interface mediated by the 3 domain.

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

This study shows that C1r2s2 proteases stabilize C1q binding to surface-bound IgG, with subclass-specific effects and improved phagocytosis with hexamer-enhanced IgGs.

DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens

The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

This study shows Staphylococcal protein A inhibits IgG hexamer formation, blocking complement activation, but IgG3 can still induce complement activation despite SpA.

Binding of the motor protein SecA to the bacterial protein translocation channel SecYEG in the absence of ATP

The paper investigates how SecA remains bound to SecYEG without ATP, showing stable interactions and conformational changes that support protein translocation.