Author

K. Schroder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. K. Lagendijk· 2 shared K. R. Short· 2 shared K. Y. Chew· 2 shared L. I. Labzin· 2 shared T. Yordanov· 2 shared X. Wang· 2 shared A. F. R. d. S. Miggiolaro· 1 shared A. H. Chan· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

A. K. Lagendijk

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia.

K. Duszyc, J. von Pein, D. Ramnath, D. Currin-Ross, S. Verma, F. Lim, M. J. Sweet, K. Schroder, A. S. Yap

The paper shows that apical extrusion prevents apoptosis from triggering inflammation in epithelia by eliminating apoptotic cells before they activate an IL-8-driven inflammatory response.

bioRxiv · Feb 12, 2023Cell Biology

Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

A. H. Chan, K. Vezyrgiannis, J. B. Von Pein, X. Wang, L. I. Labzin, D. Boucher, K. Schroder

This study identifies that caspase-4 dimerisation and D289 auto-processing enable direct cleavage of pro-IL-1β, independent of the NLRP3 inflammasome.

bioRxiv · Jan 5, 2023Immunology

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

L. I. Labzin, K. Y. Chew, K. Eschke, X. Wang, T. Esposito, C. J. Stocks, J. Rae, R. Patrick, H. Mostafavi, B. Hill, T. Yordanov, C. L. Holley, S. Emming, S. Fritzlar, F. L. Mordant, , K. Schroder

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Ornithine Lipid is a Partial TLR4 Agonist and NLRP3 Activator

M. Pizzuto, L. Hurtado-Navarro, C. Molina-Lopez, J. Soubhye, M. Gelbcke, S. Rodriguez-Lopez, J.-M. Ruysschaert, K. Schroder, P. Pelegrin

This study identifies ornithine lipid as a partial TLR4 agonist and NLRP3 activator, showing it can replace LPS in phosphate-depleted environments to trigger inflammation.

bioRxiv · Jan 28, 2022Immunology

Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

H.-W. Tseng, I. Kulina, D. Girard, J. Gueguen, C. Vaquette, M. Salga, W. Fleming, B. Jose, S. Millard, A. Pettit, K. Schroder, G. Thomas, L. Wheeler, F. Genet, S. Banzet, , J.-P. Levesque

This study shows IL-1 signaling promotes neurogenic heterotopic ossification in mice and humans by activating fibro-adipogenic progenitors.

bioRxiv · Oct 19, 2021Physiology

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

L. Schimmel, K. Y. Chew, C. Stocks, T. Yordanov, P. Essebier, A. Kulasinghe, J. Monkman, A. F. R. d. S. Miggiolaro, C. Cooper, L. De Noronha, A. K. Lagendijk, K. Schroder, L. Labzin, E. J. Gordon, K. R. Short

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.

bioRxiv · Feb 14, 2021 · PreprintCell Biology