F. M. Hughson

The paper presents a cryo-EM structure of the Dsl1 membrane tethering complex bound to SNAREs, revealing structural similarities to the exocyst complex and suggesting common principles in MTC function.

This paper presents the structure of the Vps45–Tlg2 SM–Qa-SNARE complex, showing Vps45 holds Tlg2 in an open conformation, distinct from the closed conformation seen in Munc18-1–syntaxin 1 complexes.

This paper determines the structural basis of Dsl1 complex binding to ER SNAREs, showing how it anchors the complex and positions SNARE motifs for assembly.

This study shows Munc18-1 facilitates SNARE assembly by forming a template complex, and similar mechanisms are used by other SM proteins.