J. Jiao

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

This study identifies UBE2D/eff as critical for maintaining proteostasis and a youthful proteome during aging by regulating protein degradation and preventing aggregate accumulation.

Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts

This study shows that human GM-CSF and IL-3 expression in humanized mice increases immune cell infiltration in HCC tumors, improving the model's resemblance to human disease.

Tumor sialylation controls effective anti-cancer immunity in breast cancer

This study shows that tumor sialylation suppresses anti-cancer immunity in breast cancer by altering immune cell interactions and checkpoint ligands, and that inhibiting sialylation enhances immune response and therapy effectiveness.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

Nanobodies for the treatment of SARS-CoV-2 in animals: a meta-analysis

This meta-analysis evaluates the protective effects of VHHs against SARS-CoV-2 in animals, finding significant protection with low heterogeneity.

B1L regulates lateral root development by exocytic vesicular trafficking-mediated polar auxin transport

This study shows B1L regulates lateral root development by enhancing polar auxin transport through exocytic vesicle trafficking and interaction with the exocyst complex in Arabidopsis.

How public reaction to disease information across scales and the impacts of vector control methods influence disease prevalence and control efficacy

This study shows how public reaction to disease information and vector control methods affect disease prevalence and control efficacy, using a modified Ross-MacDonald model for Zika virus.

TRIM21 and PHLDA3 Negatively Regulate the Cross-Talk between the PI3K/AKT Pathway and PPP Metabolism

This study shows TRIM21 and PHLDA3 regulate cross-talk between PI3K/AKT signaling and PPP metabolism, with implications for cancer therapy.

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

This study shows Munc18-1 facilitates SNARE assembly by forming a template complex, and similar mechanisms are used by other SM proteins.

Single-molecule force spectroscopy of protein-membrane interactions

The paper quantifies protein-membrane interactions using single-molecule force spectroscopy, showing C2 domains resist forces of 2-7 pN and have binding energies of 4-14 kBT.