Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells
W. Xu, F. Ashford, S. Bitsi, L. Schiffer, F. Qadir, W. Arlt, A. Tomas, D. Hodson, F. Mauvais-Jarvis
This paper shows testosterone enhances GLP-1's ability to increase insulin secretion in male β cells by boosting cAMP production at the plasma membrane and endosomes.
bioRxiv · May 12, 2020 · PreprintPhysiology