T. Mitchell

Zfp36l1 establishes the high affinity CD8 T cell response by directly linking TCR affinity to cytokine sensing

The paper shows ZFP36L1 links TCR affinity to cytokine sensing, promoting clonal expansion of high affinity CD8 T cells through IL2 competition.

The coagulation factor IX (F9) loss of function prevents the cell cycle arrest induced by CDK4/6 inhibitors treatment

This study identifies F9 as a gene that facilitates cell cycle arrest induced by CDK4/6 inhibitors in breast cancer cells, suggesting its role in senescence and potential therapeutic implications.

TGF-B signaling suppresses TCA cycle metabolism in renal cancer.

This study shows that TGF-β signaling suppresses TCA cycle enzyme expression in renal cancer, leading to reduced mitochondrial metabolism and tumor growth.

Lipidome profiles of plasma microvesicles differ in experimental cerebral malaria, compared to malaria without neurological complications

The paper compares lipidome profiles of plasma microvesicles in experimental cerebral malaria and non-CM malaria, finding distinct lipid changes associated with CM.

Cell to cell communication is an early event in glioblastoma

This study identifies early cell-to-cell communication as a key driver in glioblastoma progression through Wg signaling and JNK pathway activation.

Gene flow between divergent cereal- and grass-specific lineages of the rice blast fungus Magnaporthe oryzae

This study uses whole-genome sequencing of 76 Magnaporthe oryzae isolates to analyze population structure and gene flow, revealing multiple divergent lineages and evidence of inter-lineage genetic exchange.