G. A. Kuhn

This paper develops an in silico model of trabecular bone remodeling in aging mice, showing how changes in OPG, RANKL, and Scl levels affect bone volume fraction.

This study uses longitudinal in vivo micro-CT to analyze fracture healing and assess biomaterials in mouse femur defects, showing collagen scaffolds often fail while BMP-2 improves healing outcomes.

This study shows that individualized cyclic mechanical loading during the remodelling phase of fracture healing in mice increases callus formation and mineralization through effects on Wnt-signalling targets.

This study uses real-time finite element analysis to apply adaptive mechanical loading to improve bone healing in a mouse vertebral defect model.

This study examines the effects of early life stress on bone homeostasis in mice and humans, finding catabolic bone changes associated with stress-related factors.

This study investigates how bone adapts to mechanical loading by analyzing the relationship between loading frequency and bone volume fraction changes, finding a logarithmic dependency.

This study assesses the impact of long-term in vivo micro-CT imaging on aging markers in mice, finding small but significant changes in bone morphology without genotype-specific effects.

This study evaluates PolgA(D257A/D257A) mice as a model for frailty and osteosarcopenia, showing accelerated health deficits and musculoskeletal deterioration compared to wild-type mice.

This study uses time-lapsed imaging to show that local mechanical strains correlate with mineralised tissue formation in a mouse bone defect model.

This study evaluates longitudinal in vivo micro-CT for monitoring fracture healing in mice, finding no significant impact on callus formation or remodeling from repeated scans.