ImmunologybioRxiv
Neuro-immune Crosstalk in the Enteric Nervous System from Early Postnatal Development to Adulthood
M. F. Viola, M. Chavero Pieres, E. Modave…·G. Boeckxstaens
This study shows that intestinal macrophages refine the enteric nervous system early in life by pruning synapses and phagocytosing neurons, and maintain neuron survival post-weaning through a TGFβ-driven microglia-like phenotype.