Author

T. Krischuns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

N. Naffakh· 5 shared C. Isel· 4 shared S. CusackiD· 4 shared S. Paisant· 4 shared D. Courtney· 2 shared A. Blondel· 1 shared A. O'Brien· 1 shared A. PflugiD· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersMicrobiology

N. Naffakh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

T. Krischuns, B. Arragain, C. Isel, S. Paisant, M. Budt, T. Wolff, S. Cusack, N. Naffakh

This study shows that host RNA polymerase II's C-terminal domain, along with ANP32, enhances influenza virus polymerase replication activity, suggesting host RNAP II anchors viral transcription and replication.

bioRxiv · Aug 1, 2023Microbiology

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

A. R. Camacho-Zarco, L. Yu, T. Krischuns, S. Dedeoglu, D. Maurin, G. Bouvignies, T. Crepin, R. W. H. Ruigrok, S. Cusack, N. Naffakh, M. Blackledge

This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.

bioRxiv · Jul 8, 2023 · PreprintBiochemistry

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

M. Dupont, T. Krischuns, Q. Giai Gianetto, S. Paisant, S. Bonazza, J.-B. Brault, T. Douche, J. I. Perez-Perri, M. W. Hentze, S. Cusack, M. Matondo, C. Isel, D. Courtney, N. Naffakh

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

bioRxiv · Mar 21, 2023 · PreprintMicrobiology

Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

T. Krischuns, C. Isel, P. Drncova, M. Lukarska, A. Pflug, S. Paisant, V. Navratil, S. Cusack, N. Naffakh

This study compares the binding interfaces of influenza B and A polymerases to the host RNA polymerase II CTD, revealing distinct evolutionary adaptations for host range.

bioRxiv · Feb 4, 2022 · PreprintMicrobiology

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

K.-Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, D. Courtney, A. O'Brien, S. Baker, C. Isel, F. Agou, Y. Jacob, A. Blondel, N. Naffakh

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.

bioRxiv · Dec 18, 2021Microbiology