Author

G. Brouhard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:structural biology· 3 Research Focus:cell signaling & trafficking· 2 Organism:Drosophila· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Z. Khalifa· 1 shared A. G. Hendricks· 1 shared A. Rafiei· 1 shared A. Sali· 1 shared A. T. Molines· 1 shared C. Black· 1 shared C. H. Edrington· 1 shared C.-T. Hsu· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

A. A. Z. Khalifa

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Author profile →

4 papers

Recent·Most cited

The mechanochemical origins of the microtubule sliding motility within the kinesin-5 domain organization

S. Nithiananatham, M. K. Iwanski, I. Gaska, H. Pandey, T. Bodrug, S. Inagaki, J. Major, G. Brouhard, L. Gheber, S. S. Rosenfeld, S. T. Forth, A. G. Hendricks, J. Al-Bassam

This study investigates how the structural features of kinesin-5, specifically tail-motor domain interactions and minifilament length, influence microtubule sliding motility and spindle organization.

bioRxiv · Oct 12, 2021 · PreprintCell Biology

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C- terminal domain

A. Rafiei, L. Lee, D. A. Crowder, D. J. Saltzberg, A. Sali, G. Brouhard, D. C. Schriemer

This study reveals how doublecortin binds to microtubules through a cooperative mechanism involving its C-terminal domain and C-tails, with implications for neurological disorders.

bioRxiv · Feb 17, 2021Biochemistry

Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization

A. T. Molines, J. Lemiere, M. Gazzola, I. E. Steinmark, C. H. Edrington, C.-T. Hsu, K. Suhling, G. Goshima, L. J. Holt, M. Thery, G. Brouhard, F. Chang

This study shows that cytoplasmic viscosity affects microtubule polymerization and depolymerization rates in fission yeast, moss, and mammalian cells.

bioRxiv · Oct 27, 2020Cell Biology

Crystal structure of human PACRG in complex with MEIG1

N. Khan, D. Pelletier, S. Veyron, N. Croteau, M. Ichikawa, C. Black, A. A. Z. Khalifa, S. Chaaban, I. Kurinov, G. Brouhard, K. H. Bui, J.-F. Trempe

The paper reports the crystal structure of human PACRG with MEIG1 and models its role in microtubule junctions, revealing interactions with tubulin and evolutionary insights.

bioRxiv · Sep 27, 2019Cell Biology