M. Ichikawa

Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists

The paper determines cryo-EM structures of P2X7 receptor with antagonists and identifies key residues for subtype specificity, aiding in antagonist design.

Structure and function of bacterial YeeE-YeeD complex in thiosulfate uptake pathway

This study investigates the YeeE-YeeD complex in thiosulfate uptake, showing YeeD's role in transport and decomposition, and presents their structural interactions.

Spontaneous myocarditis in mice predisposed to autoimmune disease: Including Vaccination-induced onset

This study shows that reduced NF-κB1 expression in NOD/ShiLtJ mice leads to severe myocarditis and insulitis, and vaccination can trigger myocarditis in these mice.

Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside

This study develops a tetrameric protein that binds to microtubules to generate stable superstructures, offering insights for nanomaterial design.

Whole-genome sequence analysis of mutations in rice plants regenerated from zygotes, mature embryos, and immature embryos

The paper analyzes whole-genome sequences of rice plants regenerated from different embryonic sources to assess somaclonal variation and mutation rates.

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-electron microscopy

This study uses cryo-electron microscopy to reveal the structure of outer dynein arms attached to microtubules and proposes a model for their remodeling and activation through molecular dynamics simulations.

Water uptake analysis in Japanese mustard spinach: A numerical approach

This study measures water uptake dynamics in Japanese mustard spinach using an experimental system and image analysis, revealing turgor movement through frequency domain analysis.

The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

The paper identifies new inner junction proteins in cilia and shows they form an interaction hub involving tubulin post-translational modifications.

Crystal structure of human PACRG in complex with MEIG1

The paper reports the crystal structure of human PACRG with MEIG1 and models its role in microtubule junctions, revealing interactions with tubulin and evolutionary insights.

Identification and mapping of central pair proteins by proteomic analysis

The paper identifies 37 novel central pair (CP) protein candidates through proteomic analysis of Chlamydomonas mutants and presents a more complete model of CP protein localization.

A solvable model of entrainment ranges for the circadian rhythm under light/dark cycles

This paper develops a continuous model to analyze circadian rhythm entrainment under light/dark cycles and finds that entrainment ranges vary among organisms, with plants showing larger ranges than mammals.

Tubulin Lattice in Cilia is in a Stressed Form Regulated by Microtubule Inner Proteins

This study presents the near-atomic structure of Tetrahymena doublet microtubules, showing that microtubule inner proteins stabilize the tubulin lattice and contribute to the intrinsic stress in cilia.