G. E. Reid

This study shows hypoxia-induced lipid remodeling in pancreatic cancer cells increases migratory potential without altering membrane biophysical properties.

The paper uses protein painting to show how pharmacological stimuli remodel conserved proteostasis machinery across the proteome in whole cells.

The paper shows proteome folding stability censuses are unreliable due to hidden information on conformation and ligand binding.

This study expresses nine human GBA2 isoforms in COS-7 cells and finds that only isoform 1 shows significant activity in hydrolyzing GlcCer, affecting sphingolipid levels.

This study identifies a novel role for sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids, showing that its absence leads to their accumulation in the brain due to slower catabolism.

This study shows that arginine valency in C9ORF72 DPRs causes promiscuous proteome binding, ribosome stalling, actin cytoskeleton disruption, and arginine hypomethylation.

The paper measures proteome solubility changes in Neuro2a cells under various protein homeostasis stresses and finds widespread remodelling with specific patterns of solubility shifts.