Author

X. Sui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Plant Biology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

J. Wang· 3 shared C. Li· 2 shared C. Liu· 2 shared H. Wu· 2 shared K. Li· 2 shared M. Liao· 2 shared P. Liu· 2 shared S. Wang· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

J. Wang

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10 papers

Recent·Most cited

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

K. Li, C. Liu, C. Li, T. Zhang, T. Zhao, D. Zhang, H. Wu, Y. Liu, S. Wang, Y. Yang, B. Lin, W. Wang, J. Wang, X. Sui, X. Chen, P. Liu

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Cell Stem Cell · Aug 1, 2025Peer-reviewedCancer Biology

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

C. Liu, K. Li, X. Sui, T. Zhao, T. Zhang, Z. Chen, H. Wu, C. Li, H. Li, F. Yang, Z. Liu, Y.-Y. Lu, J. Wang, X. Chen, P. Liu

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

bioRxiv · Dec 11, 2023 · PreprintCancer Biology

Ferroptosis induced by phenolic compound-iron complex

X. Sui, J. Wang, Z. Zhao, B. Liu, M. Liu, M. Liu, C. Shi, X. Feng, Y. Fu, D. Shi, S. Li, Q. Qi, M. Xian, G. Zhao

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

bioRxiv · May 23, 2023 · PreprintMicrobiology

Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in aging

X. Sui, M. A. Prado, J. A. Paulo, S. P. Gygi, D. Finley, R. I. Morimoto

This study examines how proteome conformational stability changes in aging C. elegans due to missense mutations and polyglutamine expansions, revealing age-dependent metastable protein networks.

bioRxiv · Sep 28, 2022 · PreprintBiochemistry

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7

K. Wang, C.-W. Lee, X. Sui, S. Kim, S. Wang, A. B. Higgs, A. J. Baublis, G. A. Voth, M. Liao, T. C. Walther, R. V. Farese

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

bioRxiv · Sep 15, 2022 · PreprintBiochemistry

The PRC2-dependent epigenetic reprograming of the bladder epithelium exacerbates urinary tract infections

C. Guo, M. ZHAO, X. Sui, Z. Balsara, P. Zhu, X. S. Li

This study shows that PRC2-dependent epigenetic reprogramming in bladder urothelium worsens UTIs by promoting inflammation and impaired differentiation, and that inhibiting Ezh2 can improve disease outcomes.

bioRxiv · Oct 22, 2020 · PreprintImmunology

Unravel the Mystery of NIC1-locus on Nicotine Biosynthesis Regulation in Tobacco

X. Sui, H. Xie, Z. Tong, H. Zhang, Z. Song, Y. Gao, L. Zhao, W. Li, M. Li, Y. Li, Y. Li, B. Wang

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

bioRxiv · Jul 4, 2020 · PreprintPlant Biology

Arabidopsis CPR5 regulates ethylene signaling via interacting with ETR1 N-terminus and controlling mRNAs nucleocytoplasmic transport

J. Chen, Y. Yu, X. Sui, L. Qiao, C.-H. Dong

This study shows CPR5 regulates ethylene signaling by interacting with ETR1's N-terminal domains and controlling mRNA nucleocytoplasmic transport.

bioRxiv · Dec 3, 2019 · PreprintPlant Biology

Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

X. Sui, D. E. V. Pires, S. Nie, G. Vecchi, M. Vendruscolo, D. B. Ascher, G. E. Reid, D. M. Hatters

The paper measures proteome solubility changes in Neuro2a cells under various protein homeostasis stresses and finds widespread remodelling with specific patterns of solubility shifts.

bioRxiv · Jul 26, 2019Biochemistry

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin

X. Sui, H. Arlt, K. Brook, Z. W. Lai, F. DiMaio, D. Marks, M. Liao, R. Farese, T. Walther

The paper reports the cryo-EM structure of D. melanogaster seipin and proposes a model for its role in lipid droplet formation.

bioRxiv · Sep 14, 2018Cell Biology