Author

G. L. Edmunds

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Wuelfing· 3 shared D. J. Morgan· 3 shared H. Alamir· 2 shared R. Ambler· 2 shared A. Alsubaiti· 1 shared A. M. Gallimore· 1 shared C. J. Holland· 1 shared C. W. C. Wong· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

C. Wuelfing

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3 papers

Recent·Most cited

ImmunologybioRxivAug 3, 2023

TIM3 is a context-dependent co-regulator of cytotoxic T cell function

H. Alamir, C. W. C. Wong, A. Alsubaiti…·C. Wuelfing

This study shows TIM3 inhibits spheroid-suppressed CTL but not active CTL, and its function depends on the context of T cell activation and ligand expression.

DOI 10.1126/scisignal.adk4594

mousehuman

𝕏 PostBluesky

ImmunologybioRxivMay 20, 2021

The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization

G. L. Edmunds, C. W. L. Wong, R. Ambler…·D. J. Morgan

This study identifies adenosine 2a receptor and TIM3 as inhibitors of CTL-mediated tumor cell killing by interfering with cytoskeletal polarization and infiltration.

DOI 10.1038/s42003-021-02972-8

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivOct 16, 2018

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor

R. Ambler, G. L. Edmunds, G. Toti…·C. Wuelfing

The paper investigates how PD-1 signaling affects CD8+ T cell interactions with tumor cells, finding that PD-1 suppresses cell couple maintenance and tumor cell killing by impairing actin dynamics.

DOI 10.1126/scisignal.aau4518

humanimaging

𝕏 PostBluesky