Author

G. Link

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Hausser· 1 shared A. Knox· 1 shared A. L. Green· 1 shared I. Balakrishnan· 1 shared J. DeSisto· 1 shared J. E. Burke· 1 shared K. Hirzel· 1 shared M. A. H. Parson· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. Hausser

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2 papers

Recent·Most cited

PRMT5 maintains tumor stem cells to promote pediatric high-grade glioma tumorigenesis

J. DeSisto, I. Balakrishnan, A. Knox, G. Link, S. Venkataraman, R. Vibhakar, A. L. Green

This study identifies PRMT5 as essential for pediatric high-grade glioma growth by maintaining tumor stem cells, showing that its inhibition reduces self-renewal and improves survival in preclinical models.

bioRxiv · Mar 12, 2024Cancer Biology

PKD autoinhibition in trans regulates activation loop autophosphorylation in cis

R. Reinhardt, K. Hirzel, G. Link, S. A. Eisler, T. Haegele, M. A. H. Parson, J. E. Burke, A. Hausser, T. A. Leonard

This study shows PKD is regulated by trans-autoinhibition followed by cis autophosphorylation, switching the kinase on by preventing re-autoinhibition.

bioRxiv · May 5, 2022Biochemistry