Author

I. Balakrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:ChIP-seq· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. Vibhakar· 4 shared S. Venkataraman· 4 shared D. Wang· 3 shared A. Green· 2 shared A. Pierce· 2 shared E. Danis· 2 shared J. DeSisto· 2 shared N. A. Dahl· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

R. Vibhakar

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

I. Balakrishnan, K. Madhavan, A. M. Pierce, J. A. Michlin, B. Brunt, S. L. Chetty, D. Wang, J. DeSisto, Z. Nuss, N. Davidson, A. Donson, K. Jones, S. S. Mitra, A. Green, N. Dahl, , S. Venkataraman

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

bioRxiv · Mar 19, 2024 · PreprintCancer Biology

PRMT5 maintains tumor stem cells to promote pediatric high-grade glioma tumorigenesis

J. DeSisto, I. Balakrishnan, A. Knox, G. Link, S. Venkataraman, R. Vibhakar, A. L. Green

This study identifies PRMT5 as essential for pediatric high-grade glioma growth by maintaining tumor stem cells, showing that its inhibition reduces self-renewal and improves survival in preclinical models.

bioRxiv · Mar 12, 2024Cancer Biology

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

F. M. Walker, L. Martin Sobral, E. Danis, B. Sanford, I. Balakrishnan, D. Wang, A. Pierce, S. D. Karam, N. J. Serkova, N. K. Foreman, S. Venkataraman, R. Dowell, R. Vibhakar, N. A. Dahl

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology

Super elongation complex as a targetable dependency in diffuse midline glioma

N. A. Dahl, E. Danis, I. Balakrishnan, D. Wang, A. Pierce, F. Walker, A. Gilani, N. Serkova, K. Madhaven, S. Fosmire, A. Green, N. K. Foreman, S. Venkataraman, R. Vibhakar

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

bioRxiv · Jan 22, 2020Cancer Biology