R. Vibhakar

Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

PRMT5 maintains tumor stem cells to promote pediatric high-grade glioma tumorigenesis

This study identifies PRMT5 as essential for pediatric high-grade glioma growth by maintaining tumor stem cells, showing that its inhibition reduces self-renewal and improves survival in preclinical models.

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

Neoplastic and Immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.

The paper uses single-cell transcriptomics to identify subgroup-specific neoplastic and immune cell heterogeneity in childhood medulloblastoma.

The long non-coding RNA lnc-HLX-2-7 is oncogenic in group 3 medulloblastomas

This study identifies lnc-HLX-2-7 as an oncogenic lncRNA in group 3 medulloblastomas, showing it promotes tumor growth and is regulated by MYC and JQ1.

Super elongation complex as a targetable dependency in diffuse midline glioma

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.