TPX2 expression promotes sensitivity to dasatinib in breast cancer by activating the YAP transcriptional signaling.
C. Marugan, B. Ortigosa, N. Sanz-Gomez…·G. de Carcer
The paper identifies TPX2 as a gene that increases breast cancer sensitivity to dasatinib by activating the YAP pathway, and shows TPX2 and YAP are biomarkers for poor prognosis and potential dasatinib therapy.