L. Martinez

Anti-inflammatory immunomodulation for the treatment of Congenital Diaphragmatic Hernia

This study shows that atypical TLR2/4 ligands can cure congenital diaphragmatic hernia in animal models by promoting M2 macrophage infiltration and retinoic acid pathway activation.

Gasdermin B over-expression arbitrates HER2-targeted therapy resistance by inducing protective autophagy

This study identifies GSDMB over-expression as a driver of HER2-targeted therapy resistance through autophagy induction and shows that combining lapatinib with chloroquine enhances therapeutic efficacy in GSDMB-positive tumors.

Piezo mechanosensory channels regulate centrosome integrity

This study shows Piezo1 and 2 regulate centrosome integrity by modulating Ca2+ levels through mechanotransduction of cell intrinsic forces.

Specific telomere protection ensured by FOXO3a upon genotoxic stress and during aging

The paper shows FOXO3a protects telomeres during aging and genotoxic stress, linking it to longevity pathways.

IN VIVO ANALYSIS OF THE ROLE OF GASDERMIN-B (GSDMB) IN CANCER USING NOVEL KNOCK-IN MOUSE MODELS

This study uses novel knock-in mouse models to investigate GSDMB2's role in cancer, finding it does not significantly drive tumorigenesis but may reduce gastric carcinogenesis.

Differences in berry primary and secondary metabolisms identified by transcriptomic and metabolic profiling of two table grape color somatic variants

The paper compares transcriptomic and metabolic profiles of two table grape cultivars with different berry skin colors, identifying differences in flavonoid and primary metabolite composition and gene expression.