Author

G. Poortinga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. S. Trigos· 2 shared C. Cullinane· 2 shared E. Sanij· 2 shared G. A. McArthur· 2 shared J. Kang· 2 shared K. M. Hannan· 2 shared K. T. Chan· 2 shared R. B. Pearson· 2 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. S. Trigos

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

E. P. Kusnadi, A. S. Trigos, C. Cullinane, D. L. Goode, O. S. Larsson, J. R. Devlin, K. T. Chan, D. P. DeSouza, M. J. McConville, G. A. McArthur, G. Thomas, E. Sanij, G. Poortinga, R. D. Hannan, K. M. Hannan, , R. B. Pearson

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

bioRxiv · Mar 26, 2020Cancer Biology

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

E. Sanij, K. M. Hannan, S. Yan, X. Xuan, J. E. Ahern, K. T. Chan, J. Son, O. Kondrashova, E. Lieschke, M. J. Wakefield, A. S. Trigos, D. Frank, S. Ellis, C. Cullinane, J. Kang, , R. B. Pearson

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.

bioRxiv · Apr 29, 2019 · PreprintCancer Biology