G. Thomas

A polinton-like virus of the algae Chrysochromulina parva inhibits the growth of a newly isolated relative of Tethysvirus ontarioense

This study identifies a new Tethysvirus, CpV-BQ3, and demonstrates its interaction with a polinton-like virus, CpV-PLV Moe, showing mutualistic and antagonistic effects on algal host growth.

DACIT: Device for Axon - Cancer cell Interaction Testing in 2D and 3D

DACIT enables in vitro study of axon-cancer cell interactions in 2D and 3D by separating neuronal soma from axons and cancer cells into distinct compartments.

Bait, not reward: CO2-enriched Nepenthes pitchers secrete toxic nectar

This study shows that Nepenthes extrafloral nectar is a toxic bait, not a reward, containing acetylcholinesterase inhibitors that impair arthropod neuronal activity.

Chemical cues from beetle larvae trigger proliferation and putative virulence gene expression of a plant pathogen

The paper shows that chemical cues from beetle larvae enhance bacterial growth and virulence gene expression in a plant pathogen.

Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.

Biofilm formation in Zymoseptoria tritici

This study shows Zymoseptoria tritici forms biofilms with characteristics similar to other biofilm-forming microbes, including extracellular matrix production and stress tolerance.

SARS-CoV-2 Spike Protein Reduces Burst Activities in Neurons Measured by Micro-Electrode Arrays

This study shows that SARS-CoV-2 S1 protein reduces neuronal burst activity in vitro, while S2 does not, and this effect is blocked by an anti-S1 antibody.

Ethanolaminephosphate cytidyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

This study shows that EPCT is essential for PE synthesis, stress tolerance, and survival in Leishmania major across both promastigote and amastigote stages.

PhyloAcc-GT: A Bayesian method for inferringpatterns of substitution rate shifts and associations with binary traits under gene tree discordance

PhyloAcc-GT improves upon PhyloAcc by accounting for gene tree discordance due to incomplete lineage sorting, enhancing accuracy in detecting substitution rate shifts linked to specific lineages.

Sexual dimorphism versus biomechanical loading in occipital bone morphological variation

The paper investigates how biological sex and biomechanical loading influence occipital bone morphology, finding sexual dimorphism in foramen magnum area but limited subsistence-related variation.

Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

This study shows IL-1 signaling promotes neurogenic heterotopic ossification in mice and humans by activating fibro-adipogenic progenitors.

Treating Porcine Abscesses With Histotripsy: A Pilot Study

This study evaluates histotripsy for treating abscesses in pigs, finding cavitation histotripsy more effective at reducing bacterial load with less treatment volume.

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

The paper analyzes B cell receptor repertoires from COVID-19 patients to identify convergent immune signatures associated with disease outcome.

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α

CD4+ follicular helper-like T cells are key players in anti-tumor immunity

The paper identifies CD4+ follicular helper-like T cells as critical for enhancing anti-tumor CD8+ T cell responses and tumor growth inhibition.

Engineering transplantable jejunal mucosal grafts using primary patient-derived organoids from children with intestinal failure

This study develops a method to create transplantable jejunal mucosal grafts using patient-derived organoids and decellularized scaffolds, demonstrating functional grafts in vitro and in vivo.

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.