Author

G. Sciume

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

P.-Y. Rohan· 2 shared S. Urcun· 2 shared W. Skalli· 2 shared A. Filby· 1 shared A. McCurdy· 1 shared A. Santoni· 1 shared A. Scheer· 1 shared A. Shapanis· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

P.-Y. Rohan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Non-operable glioblastoma: proposition of patient-specific forecasting by image-informed poromechanical model

S. Urcun, D. Baroli, P.-Y. Rohan, W. Skalli, V. Lubrano, S. Bordas, G. Sciume

The paper introduces a patient-specific image-informed poromechanical model to forecast glioblastoma progression and treatment response.

bioRxiv · Jan 10, 2023Biophysics

Programmed cell death-1 receptor mediated regulation of Tbet+ NK1.1- Innate Lymphoid Cells within the Tumor Microenvironment

M. Lim, C. Lai, G. Mallett, D. McDonald, G. Hulme, S. Laba, A. Shapanis, M. Payne, W. Patterson, M. Alexander, J. Coxhead, A. Filby, R. Plummer, P. Lovat, G. Sciume, , S. Amarnath

This paper identifies Tbet+NK1.1- ILCs in the tumor microenvironment and shows PD-1 regulates their proliferation and anti-tumor function through metabolic changes.

bioRxiv · Sep 21, 2022 · PreprintImmunology

Mechanistic modeling of vascular tumor growth: an extension of Biot's theory to hierarchical bi-compartment porous medium system

The paper extends Biot's theory to model vascular tumor growth as a hierarchical bi-compartment porous medium, coupling vascular and extra-vascular mechanics with angiogenesis.

bioRxiv · Jun 29, 2020Biophysics

When killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer

M. S. Hasim, M. Marotel, J. J. Hodgins, E. Vulpis, H.-Y. Shih, A. Scheer, O. MacMillan, F. Alonso, K. Burke, D. P. Cook, M. T. Petrucci, A. Santoni, P. Fallon, A. Sharpe, G. Sciume, , M. Ardolino

Natural Killer cells acquire PD-1 from tumor cells via trogocytosis, which inhibits anti-tumor immunity.

bioRxiv · Jun 26, 2020Immunology

Digital twinning of Cellular Capsule Technology: emerging outcomes from the perspective of porous media mechanics

S. Urcun, P.-Y. Rohan, W. Skalli, P. Nassoy, S. P. A. Bordas, G. Sciume

This paper develops a multiphase poro-mechanical model to analyze tumor growth in alginate capsules, showing that experimental pressure measurements do not directly reflect tumor cell pressure and highlights parameter differences between encapsulated and free growth.

bioRxiv · Jun 9, 2020Biophysics