M. Alexander

Detailed Social Network Interactions and Gut Microbiome Strain-Sharing Within Isolated Honduras Villages

The paper investigates how social network interactions influence microbiome composition in isolated Honduran villages using social network and microbiome sequencing data.

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

Development of an MR-guided focused ultrasound (MRgFUS) lesioning approach for small and deep structures in the rat brain

This paper develops an MR-guided focused ultrasound lesioning method for small and deep brain structures in rats, achieving improved targeting accuracy.

Programmed cell death-1 receptor mediated regulation of Tbet+ NK1.1- Innate Lymphoid Cells within the Tumor Microenvironment

This paper identifies Tbet+NK1.1- ILCs in the tumor microenvironment and shows PD-1 regulates their proliferation and anti-tumor function through metabolic changes.

Systems biology illuminates alternative metabolic niches in the human gut microbiome

This study identifies the metabolic niche of Eggerthella lenta in the human gut by combining experimental and computational approaches, revealing its use of acetate and arginine catabolism.

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

This study uses phage-delivered CRISPR-Cas9 to deplete specific E. coli strains and induce genomic deletions in the gut microbiome of mice.

NR2F1 is a barrier to dissemination of early-evolved mammary cancer cells

The paper identifies NR2F1 as a barrier to early dissemination of HER2+ mammary cancer cells, showing its regulation by tumor suppressive and oncogenic pathways and its role in epithelial-mesenchymal transition.

ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2

This study shows that ILRUN inhibits SARS-CoV-2 replication by downregulating ACE2 expression and blocking viral entry into human cells.

A diet-dependent enzyme from the human gut microbiome promotes Th17 cell accumulation and colitis

Perturbation of the human gut microbiome by a non-antibiotic drug contributes to the resolution of autoimmune disease

This study shows that methotrexate, a non-antibiotic drug, alters the human gut microbiota, favoring Firmicutes over Bacteroidetes, which correlates with improved drug response in rheumatoid arthritis patients.