G. V. Raghuram

The paper shows that metastases form de novo in target organs when chromatin particles from dying cancer cells transform local cells into new cancers.

The paper shows that cell-free chromatin particles from dying cells trigger immune responses in human lymphocytes via the cGAS-STING pathway.

The paper shows that cell-free chromatin particles activate multiple immune checkpoints in human T cells, suggesting a new approach for cancer immunotherapy.

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

The paper shows that cell-free chromatin particles from dying cells cause mtDNA damage and ROS production in healthy cells, suggesting they are key triggers for oxidative stress-related diseases.