R. Lopes

Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells

Cell-free chromatin particles from dying cells promote the induction of an immune response in human lymphocytes

The paper shows that cell-free chromatin particles from dying cells trigger immune responses in human lymphocytes via the cGAS-STING pathway.

Cell-free chromatin particles activate immune checkpoints in human T cells: Implications for cancer therapy

The paper shows that cell-free chromatin particles activate multiple immune checkpoints in human T cells, suggesting a new approach for cancer immunotherapy.

Genetic and epigenetic driven variation in regulatory regions activitycontribute to adaptation and evolution under endocrine treatment

This study identifies non-coding DNA alterations in hormone-dependent breast cancer that contribute to endocrine therapy resistance and disease progression.

Cell-free chromatin particles released from dying cells inflict mitochondrial damage and ROS production in living cells

The paper shows that cell-free chromatin particles from dying cells cause mtDNA damage and ROS production in healthy cells, suggesting they are key triggers for oxidative stress-related diseases.

SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray

This paper demonstrates that GCPQ, a mucoadhesive chitosan derivative, reduces SARS-CoV-2 infectivity in cell cultures and shows promising nasal retention in mice, supporting its potential as a nasal spray for COVID-19 prevention.

Comprehensive Live-cell Imaging Analysis of Cryptotanshinone and Synergistic Drug-Screening Effects in Various Human and Canine Cancer Cell Lines

The paper evaluates the anticancer effects of Cryptotanshinone (CT) and synergistic drug combinations in human and canine cancer cell lines using live-cell imaging.