H. B. Akman

The paper identifies that differential translation of AURKA mRNA isoforms, regulated by miRNA and alternative polyadenylation, contributes to oncogenic activation of Aurora A in breast cancer.

This study redefines AURKA degron motifs, showing the N-terminal A-box functions as a D-box and the C-terminal D-box is not a degron but a structural motif essential for AURKA's active conformation.

The paper investigates AURKA activity regulation, finding that its inactivation at mitotic exit depends on TPX2 degradation, not AURKA destruction, and that FZR1 suppresses interphase AURKA activity.