Cell BiologybioRxiv
Cis-membrane association of human ATG8 proteins N-terminus mediates autophagy
S. Tooze, W. Zhang, T. Nishimura…·L. Thukral
This study shows that the N-termini of lipidated ATG8 proteins associate with membranes in cis, which is essential for autophagosome expansion and efficient p62 degradation.