Cis-membrane association of human ATG8 proteins N-terminus mediates autophagy
S. Tooze, W. Zhang, T. Nishimura, D. Gahlot, C. Saito, C. Davis, H. B. J. Jefferies, A. Schreiber, L. Thukral
This study shows that the N-termini of lipidated ATG8 proteins associate with membranes in cis, which is essential for autophagosome expansion and efficient p62 degradation.
bioRxiv · Jun 10, 2022Cell Biology