R. J. Wilkinson

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

This study compares inflammatory profiles in blood and pericardial fluid of HIV-1-infected individuals with latent TB, PTB, and PCTB, finding site-specific elevation of analytes and HLA-DR as a better TB diagnostic marker.

The paper examines Mtb-specific CD4 T cell responses in HIV-positive patients with TB-IRIS, finding higher IFN-gamma+CD4 T cell activation and Granzyme B expression at IRIS onset.

This study compares Mtb-specific CD4 T cell profiles in pericardial fluid and blood from PCTB patients, finding distinct phenotypes in PCF with no difference in cytokine production.

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

This paper develops a flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria, showing it can detect cell aggregates and reveal subpopulation dynamics not captured by traditional CFU counting.

The paper analyzes drug-resistant Mtb genomes from HIV coinfected and HIV negative patients, finding that HIV coinfected patients have more low fitness rpoB variants in rifampicin-resistant strains.

The paper develops a fixed repertoire of blood transcriptome modules based on co-expression patterns across immunological states to provide a stable framework for analyzing and interpreting blood transcriptome data.

This study uses RNA-sequencing on TB sputum to reveal host metabolic shifts and microbial cholesterol catabolism during tuberculosis transmission.

The paper identifies Th22 cells as a major contributor to mycobacterial CD4+ T cell responses and shows their depletion in HIV-infected individuals.

The paper finds elevated levels of LRRK2 and α-synuclein in CSF of infectious meningitis patients, suggesting a link between neuroinflammation and infection.

This study shows that Mycobacterium tuberculosis forms intracellular cords in human lymphatic endothelial cells, evading xenophagy via the ESX-1 system and PDIM lipid.

The paper develops a targeted transcriptome fingerprinting assay using modular transcriptional repertoires to assess immune functions in clinical settings.

The paper identifies a modular transcriptional signature for active tuberculosis that distinguishes it from latent infection and other diseases, showing dynamic heterogeneity in tuberculosis contacts.