Cancer BiologybioRxiv
FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma
K. Gillis, W. A. Orellana, E. Wilson…·E. Snyder
This study shows FoxA1/2 reprogram the epigenome of NKX2-1-negative lung adenocarcinoma to drive a gastric lineage switch through DNA demethylation and regulatory element activation.
DOI 10.1016/j.devcel.2024.10.009