A. Porter

Excess dietary sodium partially restores salt and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron

This study shows that excess dietary sodium partially restores electrolyte imbalance and kidney injury markers in GRP170-deficient mice but not weight or tubule integrity.

Oncogenic drivers dictate immune control of acute myeloid leukemia.

This study shows that specific AML oncogenes influence immune responses and escape mechanisms, with NrasG12D promoting anti-leukemia immunity that can be counteracted by Myc.

Validity Assessment of Michigan's Proposed qPCR Threshold Value for Rapid Water-Quality Monitoring of E. coli Contamination

The paper assesses the validity of Michigan's proposed qPCR threshold value for E. coli by comparing its performance with culture-based methods on test and training data.

Isolated Grauer's gorilla populations differ in diet and gut microbiome

The study examines diet and gut microbiome differences in three isolated Grauer's gorilla populations, finding population-specific profiles and co-variation between diet and microbiome.

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

This study confirms the presence of nuclear alpha-synuclein in human brain tissue from dementia with Lewy bodies cases and identifies its aggregation into pathological assemblies in the nucleus.

Monoclonal antibodies targeting surface exposed epitopes of Candida albicans cell wall proteins confer in vivo protection in an infection model

The paper develops monoclonal antibodies targeting Candida albicans cell wall proteins that show improved survival and fungal burden reduction in mouse models of systemic candidiasis.

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

This study shows UVR-induced collagen degradation by fibroblasts reduces melanoma invasion and improves survival, but melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis.

The generation of a comprehensive spectral library for the analysis of the guinea pig proteome by SWATH-MS.

The paper generates a comprehensive spectral library for guinea pig proteome analysis using SWATH-MS, enabling improved quantitative proteomics in this model organism.

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

This study identifies sex-specific predictors of survival in glioblastoma patients using MR imaging and clinical data.