Cancer BiologybioRxiv
Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis
K. K. Chaudagar, H. Hieromnimon, A. Kelley…·A. Patnaik
This study shows that blocking lactate-producing pathways in PTEN/p53-deficient prostate cancer enhances macrophage phagocytosis, leading to durable tumor control in mice.
DOI 10.1158/1078-0432.ccr-23-1441