Pharmacology & ToxicologybioRxiv
Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design
S. G. Mays, A. R. Flynn, J. L. Corneilson…·E. A. Ortlund
This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.
DOI 10.1021/acs.jmedchem.9b00753