Author

A. R. Flynn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:human· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

C. D. Okafor· 2 shared E. A. Ortlund· 2 shared E. J. Millings· 2 shared G. Wang· 2 shared S. G. Mays· 2 shared X. Huang· 2 shared A. Patel· 1 shared D. D. Moore· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

C. D. Okafor

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Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 1, 2020

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

S. G. Mays, E. H. D'Agostino, A. R. Flynn…·E. A. Ortlund

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

DOI 10.1101/2020.09.01.278291

mouseproteomics

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivMay 17, 2019

Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

S. G. Mays, A. R. Flynn, J. L. Corneilson…·E. A. Ortlund

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.

DOI 10.1021/acs.jmedchem.9b00753

humanproteomics

𝕏 PostBluesky