C. D. Okafor

This study identifies distinct allosteric signaling circuits used by active and inactive ligands to communicate with the AFS of LRH-1, revealing new therapeutic targets and mechanisms of coregulator signaling.

The paper uses molecular dynamics simulations and experimental validation to show that conformational ensembles of nuclear receptors predict ligand-induced transcriptional responses.

The paper identifies two enhancer binding proteins that activate σ54-dependent transcription of Qrr1, a quorum regulatory RNA, in the bacterial symbiont Vibrio fischeri during host colonization.

The paper investigates how evolutionary changes in helix 10 of androgen receptors drove ligand selectivity by analyzing ancestral proteins and biophysical mechanisms.

This paper investigates the regulation of the HigBHigA toxin-antitoxin pair from plasmid Rts1 in Proteus vulgaris, finding it functions as an on/off transcriptional switch rather than a molecular rheostat.

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

This paper investigates the assembly of the diiron cofactor in the SznF enzyme, revealing structural changes and an unexpected glutamate ligand that aids in function assignment.

This study identifies the StarD domain of Them1 as a lipid sensor that allosterically regulates its activity and localization in response to fatty acids and lysophosphatidylcholine.

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.