Cancer BiologybioRxivPreprint
Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse
I. Kats, H. S. Schreiber, M. Simovic…·A. Ernst
This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.
DOI 10.1101/2023.03.03.530989