Author

H. Sharif

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. R. Griswold· 3 shared D. A. Bachovchin· 3 shared H. Wu· 3 shared L. R. Hollingsworth· 3 shared P. Fontana· 2 shared J. A. Paulo· 1 shared J. C. Hsiao· 1 shared J. Mintseris· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

A. R. Griswold

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Author profile →

3 papers

Recent·Most cited

Structural mechanism of CARD8 regulation by DPP9

H. Sharif, L. R. Hollingsworth, A. R. Griswold, J. C. Hsiao, Q. Wang, D. A. Bachovchin, H. Wu

This study reveals how DPP9 regulates CARD8 by forming a ternary complex and shows that DPP9 inhibitors activate CARD8 inflammasomes through two distinct mechanisms.

bioRxiv · Jan 13, 2021Immunology

DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation

L. R. Hollingsworth, H. Sharif, A. R. Griswold, P. Fontana, J. Mintseris, K. B. Dagbay, J. A. Paulo, S. P. Gygi, D. A. Bachovchin, H. Wu

This study identifies DPP9 as a repressor of NLRP1 inflammasome activation by sequestering the NLRP1 C-terminus, preventing inflammation during protein turnover.

bioRxiv · Aug 14, 2020Immunology

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

L. R. Hollingsworth, L. David, Y. Li, A. R. Griswold, H. Sharif, P. Fontana, T.-M. Fu, J. Ruan, D. A. Bachovchin, H. Wu

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

bioRxiv · Jun 27, 2020Immunology