H. Strand Clemmensen

This study develops a Mycobacterium tuberculosis-specific subunit vaccine, H107, which when co-administered with BCG enhances immune responses and provides better protection than either vaccine alone.

This study shows that high in vivo antigen expression drives CD4 T cell differentiation and reduces vaccine efficacy against Mtb, while vaccination with adjuvanted antigens can maintain T cells in a less-differentiated, protective state.