P. Andersen

Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor

This study demonstrates that engineered myeloid cells expressing a PD-1-based CAR-like receptor can recognize and attack PD-L1+ solid tumors, enhancing phagocytosis and slowing tumor growth in vivo.

Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm

This paper develops a multi-model platform to study atrial fibrillation-associated genes, identifying phospholamban as a key regulator of cardiac rhythm through interactions with calcium handling proteins.

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells

This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.

A novel Mycobacterium tuberculosis-specific subunit vaccine provides synergistic immunity upon co-administration with Bacillus Calmette-Guerin

This study develops a Mycobacterium tuberculosis-specific subunit vaccine, H107, which when co-administered with BCG enhances immune responses and provides better protection than either vaccine alone.

In vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection

This study shows that high in vivo antigen expression drives CD4 T cell differentiation and reduces vaccine efficacy against Mtb, while vaccination with adjuvanted antigens can maintain T cells in a less-differentiated, protective state.

Nanotrap(R) particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free medium methods

This paper introduces a method using Nanotrap(R) particles to improve SARS-CoV-2 detection in pooled samples, saliva, and transport medium by concentrating virus before RNA extraction.

Large particle fluorescence-activated cell sorting enables high quality single cell RNA-sequencing and functional analysis of adult cardiomyocytes

This study demonstrates that large-particle fluorescence-activated cell sorting (LP-FACS) improves the isolation of viable adult cardiomyocytes, enabling high-quality single-cell RNA sequencing and functional analysis.

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

This study shows that concurrent M. tuberculosis infection in macaques provides strong protection against secondary infection.