H. Torosyan

Structural insights into regulation of the PEAK3 scaffold by 14-3-3

This paper reports the cryo-EM structure of PEAK3 pseudokinase in complex with 14-3-3, revealing an asymmetric binding mechanism and identifying Protein Kinase D as a regulator.

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

This study identifies CNPY4 as a negative regulator of the Hedgehog pathway by modulating membrane sterol lipid levels, revealing a new mechanism of pathway regulation.