O. D. Klein

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Vole genomics links determinate and indeterminate growth of teeth

This study identifies dental genes under positive selection in voles with different molar root structures, linking genetic changes to tooth growth patterns.

YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution

The paper identifies YAP-driven reprogramming of oral epithelial stem cells into tumor-initiating cells using single-cell multiomics, revealing conserved transcriptional programs linked to poor patient survival.

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

This study identifies NOTCH3 as a driver of meningioma tumorigenesis and radiotherapy resistance, showing its role in tumor growth and survival in preclinical models.

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

A Suite of Mouse Reagents for Studying Amelogenesis

The paper develops and validates twelve mouse alleles to study ameloblast differentiation stages and enamel formation, enabling targeted analysis of enamel matrix proteins and their roles in development.

A 3D Clinical Face Phenotype Space of Genetic Syndromes using a Triplet-Based Singular Geometric Autoencoder

This paper develops a triplet-based geometric autoencoder to create a clinical face phenotypic space for syndrome diagnosis, showing it can classify syndromes, generalize to new ones, and preserve genetic disease relationships.

Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

This study identifies CNPY4 as a negative regulator of the Hedgehog pathway by modulating membrane sterol lipid levels, revealing a new mechanism of pathway regulation.

Lgr5+ telocytes are a signaling hub at the intestinal villus tip

The paper identifies Lgr5+ telocytes at the intestinal villus tip as signaling hubs that regulate epithelial gene zonation through Bmp and Wnt5a signals.

Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

This study shows lactoferrin reverses methotrexate-induced epithelial barrier defects by inhibiting TGF-β mediated epithelial-mesenchymal transition in intestinal models.

LRH-1 Mitigates Intestinal Inflammatory Disease by Maintaining Epithelial Homeostasis and Cell Survival

This study shows that LRH-1 maintains intestinal epithelial homeostasis and cell survival, and its overexpression mitigates inflammatory damage in IBD models.

The actin cytoskeleton governs apical mitosis and daughter cell dispersion in intestinal epithelia

The paper investigates how actin cytoskeleton rearrangements during mitosis in intestinal epithelial cells lead to apical DNA positioning and daughter cell dispersion.

Tissue Folding by Mechanical Compaction of the Mesenchyme

This study shows mechanical compaction of mesenchyme drives tissue folding in vitro through ECM strain and collagen alignment, without genetic engineering.