Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase
S. Jang, C. Kang, H.-S. Yang, T. Jung, H. Hebert, K. Y. Jung, S. J. Kim, S. Hohng, J.-J. Song
The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.
bioRxiv · Dec 31, 2018Biophysics