BiophysicsbioRxiv
Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase
S. Jang, C. Kang, H.-S. Yang…·J.-J. Song
The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.
DOI 10.1101/gad.323790.118