C. Kang

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana

The paper determines the crystal structure of the full-length luminal part of glycosylated VSR1 from Arabidopsis thaliana, providing insights into its tertiary and quaternary structure.

The Discovery and Characterization of 1,4-Dihydroxy-2-naphthoic Acid Prenyltransferase Involved in the Biosynthesis of Anthraquinones in Rubia cordifolia

This study identifies and characterizes RcDT1, a prenyltransferase involved in anthraquinone biosynthesis in Rubia cordifolia, and shows its evolutionary origin from the ubiquinone pathway.

Mimicry in motion: A grasshopper species that looks like, and moves like, a sympatric butterfly

This study examines the mimicry between a grasshopper and a butterfly, finding strong morphological and behavioral resemblance suggesting a mimetic relationship.

Amoeboid cells undergo durotaxis with soft end polarized NMIIA

The paper shows amoeboid cells, like T cells and neutrophils, can durotax by polarizing NMIIA towards softer substrates, and this behavior is conserved in Dictyostelium.

A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

This study identifies AeHGO, a CAD-like enzyme, as the branch point enzyme in the shikonin biosynthetic pathway of A. euchroma, showing it catalyzes reversible oxidation/reduction of key intermediates.

The roles and evolution of the four LEAFY homologues in floral patterning and leaf development in woodland strawberry

This study identifies the functional roles and evolutionary divergence of four LFY homologues in woodland strawberry, showing that only FveLFYa is critical for floral patterning.

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Effects of carbon, nitrogen, phosphorus, and potassium on flowering and Fruiting of Glycyrrhiza uralensis

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region

This study identifies the N-terminal region of CHD7 as critical for its ATPase activity and nucleosome remodeling through interactions with the nucleosome acidic patch.

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS-mTOR signaling and vascular function

This study shows that SWELL1 regulates endothelial AKT-eNOS and mTOR signaling, affecting vascular function and contributing to hypertension and vascular narrowing in Type 2 diabetes.

Yeast Chd1p remodels nucleosomes with unique DNA unwrapping and translocation dynamics

This study uses single-molecule techniques to show that yeast CHD1 remodels nucleosomes through unique DNA unwrapping and translocation dynamics involving ATP binding and hydrolysis.

Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA

The paper uses single-molecule fluorescence to show that RNA release precedes RNA polymerase dissociation during bacterial intrinsic termination, revealing a recycling stage where RNAP diffuses and can reinitiate transcription.

Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase

The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.

Substrate channeling in oxylipin biosynthesis through a protein complex in the plastid envelope of Arabidopsis thaliana

The paper identifies a molecular branch point in oxylipin biosynthesis regulated by a protein complex involving CYP74A and CYP74B enzymes in Arabidopsis thaliana.

Molecular parallelism in fast-twitch muscle proteins in echolocating mammals

The paper identifies parallel amino acid substitutions in fast-twitch muscle proteins of echolocating bats and toothed whales, suggesting a role in convergent evolution of superfast muscle physiology for echolocation.

SWELL1 is a glucose sensor required for β-cell excitability and insulin secretion

This study identifies SWELL1 as a glucose sensor in β-cells that links glucose-induced swelling to chloride current activation, which is required for glucose-stimulated insulin secretion.