J.-J. Song

This study shows that Huntingtin (HTT) binds to F-actin, bundles actin filaments, and modulates the association of Drebrin1 with actin, affecting axonal growth and cytoskeletal organization in neurons.

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

The paper investigates how Caf1 regulates Ash1's histone methyltransferase activity by sensing unmodified histone H3K4, revealing a regulatory crosstalk between H3K4 and H3K36 methylation.

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

The paper reports the cryo-EM structure of human SSTR2 bound to somatostatin, revealing ligand binding specificity and interactions with Gi proteins.

This paper introduces a programmable method to create tunable, multi-valent protein assemblies called prodrimers, showing enhanced binding affinity and cytotoxicity.

This study identifies the N-terminal region of CHD7 as critical for its ATPase activity and nucleosome remodeling through interactions with the nucleosome acidic patch.

This study uses single-molecule techniques to show that yeast CHD1 remodels nucleosomes through unique DNA unwrapping and translocation dynamics involving ATP binding and hydrolysis.

The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.

This study investigates the structure of the Importin4_histone H3/H4_Asf1a complex and identifies key interactions between Importin4 and the histone H3 tail.