MicrobiologybioRxiv
Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1
Hannah L. Itell, Jamie Guenthoer, Daryl Humes…·Julie Overbaugh
The paper identifies SLC35A2 as a host factor that influences HIV-1 tropism by modulating glycosylation, favoring R5 over X4 infection.
DOI 10.1038/s41564-024-01806-7