Cell BiologybioRxivPreprint
Increased spontaneous Ca2+ activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?
Bruno D. M. Y. Stuyvers, Penelope A. Boyden, Ruhul Amin…·Touati Benoukraf
This study shows that increased spontaneous Ca2+ activity in cardiac Purkinje cells after myocardial infarction is due to a shift in SERCA2 isoforms, specifically increased SERCA2b and reduced SERCA2a.